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The Desert Sun published a series of articles related to HIV/AIDS. The articles include a feature profiling people living with the virus and others looking at efforts by advocates to offer culturally appropriate information on HIV to Hispanics, blacks and other minorities; the efficacy of antiretrovirals, and how the drugs are enabling people to live longer; and the potential effects of proposed state budget cuts on HIV/AIDS programs in Riverside County (Brambila, Desert Sun, 6/10).

This information was reprinted from dailyreports.kff.org with kind permission from the Henry J. Kaiser Family Foundation. You can view the entire Kaiser Daily U.S. HIV/AIDS Report, search the archives and sign up for email delivery at dailyreports.kff.org.

© Henry J. Kaiser Family Foundation. All rights reserved.

Researchers at McGill University and the affiliated Lady Davis Institute for Medical Research at Montreal’s Jewish General Hospital - along with colleagues at the University of Manitoba and the University of British Columbia - may have found a chink in the armour of the human immunodeficiency virus type 1 (HIV-1), the microorganism which causes AIDS. They have pinpointed the key cellular machinery co-opted by HIV-1 to hijack the human cell for its own benefit. Their study was published in May in the Journal of Biological Chemistry.

Once a cell is infected with HIV-1, activation of the virus’s gene generates a large HIV-1 RNA molecule known as the RNA genome. This is then transported from the cell nucleus to the inner surface of the plasma membrane. The RNA genome can produce both structural proteins and enzymes, but once it arrives at the plasma membrane it can also assemble into new copies of the virus that actually bud out of the cell. Dr. Andrew J. Mouland and his colleagues have discovered how the RNA genome gets transported - or trafficked - from the nucleus to the plasma membrane.

“There is a highway inside the human cell,” explained Dr. Mouland, Associate Professor at McGill’s Departments of Medicine and Microbiology and Immunology and head of the HIV-1 RNA Trafficking Laboratory at the Lady Davis Institute. “When you drive your car to Toronto you’re ‘trafficking’ the items in your trunk. Similarly, what we have shown is that HIV-1 commandeers the host cell’s endosomal machinery to traffic its structural proteins and RNA genome. Imagine that it’s essentially jumping on board for the ride and directing it to where it needs to go. This trafficking can occur very fast in cells; so this is how these key components of HIV-1 so efficiently get to the plasma membrane, where the virus can begin to assemble.

“The RNA genome is critical, because if it doesn’t get trafficked to the right place at the plasma membrane, the virus will not be infectious,” he explained.

This discovery is extremely exciting, Dr. Mouland said, because now that researchers understand a little more about how the cell’s transport machinery is hijacked by HIV-1, they have hopes that they can now begin to devise strategies to block the process.

This work is substantiated by a co-submitted manuscript from the group of Édouard Bertrand at the Institut de genetique moleculaire de Montpellier, Centre national de recherche scientifique. The Bertrand group will publish its work in the same journal in June, 2009.

Source:
Mark Shainblum

McGill University

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At a discussion on minority health issues at the White House this week, HHS Secretary Kathleen Sebelius said the Obama administration is committed to addressing racial health care disparities, including the higher rates of HIV/AIDS among blacks, the AP/Seattle Post-Intelligencer reports. The White House issued a summary report indicating that blacks are more likely than whites to have certain conditions and diseases, including HIV/AIDS. Sebelius said the increasing rates of HIV/AIDS among blacks is one of “the most troubling” developments in U.S. health care. Separately, members of the Congressional Black Caucus, the Congressional Hispanic Caucus and the Congressional Asian Pacific American Caucus “warned Democratic leaders that any health care overhaul that ignores health gaps between whites and minorities will face stiff opposition,” according to the AP/Post-Intelligencer. The 91 members of the caucuses said they will introduce legislation this week that includes their priorities for health care reform (Evans, AP/Seattle Post-Intelligencer, 6/9).

This information was reprinted from dailyreports.kff.org with kind permission from the Henry J. Kaiser Family Foundation. You can view the entire Kaiser Daily U.S. HIV/AIDS Report, search the archives and sign up for email delivery at dailyreports.kff.org.

© Henry J. Kaiser Family Foundation. All rights reserved.