Thailand’s Office of Welfare Promotion, Protection and Empowerment of Vulnerable People earlier this week held a public hearing to discuss various risks facing the country’s children, including HIV/AIDS, Thailand’s The Nation reports. The office plans to present a draft report on the state of child rights in the country. The report will be sent through the Foreign Affairs Ministry to the United Nations’ Convention on the Rights of the Child in July, according to ministry deputy director Saran Samarnphan. Young people were among some of the attendees at the public hearing, according to The Nation.

Youth representative Natkamon Tumpaeng said that the government has not provided adequate sex education to young people, which has resulted in unwanted pregnancies and the spread of HIV. He said, “Without sex education, many youths have clearly engaged in unsafe sex.” Passacha Pachuen, a public relations official for a council on children and youth in the Surin province, said that at many schools, teachers are forcing sex on students. “Many teachers demand sex or other favors from their students in exchange for good grades,” Passacha said. In addition, Amnat Siangsawas, the deputy chair of the council of youth and children in the city of Nakhon Sawan, said that a lack of resources often leads many children into the labor market, where they are being exploited. Amnat added that officials should “put in place mechanisms that will help them” (The Nation, 5/13).

Reprinted with kind permission from http://www.kaisernetwork.org. You can view the entire Kaiser Daily Health Policy Report, search the archives, or sign up for email delivery at http://www.kaisernetwork.org/dailyreports/healthpolicy. The Kaiser Daily Health Policy Report is published for kaisernetwork.org, a free service of The Henry J. Kaiser Family Foundation.

© 2009 Advisory Board Company and Kaiser Family Foundation. All rights reserved.

Researchers have successfully blocked SIV, the simian version of HIV, using a new technique that could help lead to the development of an effective HIV/AIDS vaccine, the Children’s Hospital of Philadelphia. The team also included scientists from Nationwide Children’s Hospital in Columbus, Ohio, and the New England Primate Research Center in Boston.

Johnson and colleagues developed a genetically altered virus that carried the vaccine candidate and injected it into the muscles of monkeys. The vaccine prompted the muscles to produce a protein that is designed to bind to SIV and prevent it from infecting cells (Goldstein, Philadelphia Inquirer, 5/18). After treating nine monkeys with the vaccine candidate for one month, the researchers injected them with SIV. Six monkeys were not administered the vaccine candidate before being injected with SIV. None of the immunized monkeys developed AIDS, while three showed indications of SIV infection. Researchers detected high concentrations of the proteins in their blood one year later. All six non-immunized monkeys became infected with SIV, and four died during the trial (Schmid, AP/Austin American-Statesman, 5/18). The DNA used in the carrier virus can deliver DNA into the cells of both monkeys and humans, according to the Inquirer.

Johnson said that the results of the trials were so encouraging that he plans to request approval from FDA to begin clinical trials in humans, the Inquirer reports. However, he said that there is “no guarantee that things that work in monkeys will work in humans,” adding that an HIV/AIDS vaccine could be 10 years away (Philadelphia Inquirer, 5/18). Recent HIV/AIDS vaccine failures prompted the researchers to try a different route that involved “bypassing the natural immune system that was the target of all previous HIV and SIV vaccines candidates,” Johnson said. “Some years ago I came to the conclusion that HIV was different from other viruses … and we might not ever be able to use traditional approaches,” he added (AP/Austin American-Statesman, 5/18).

Peggy Johnson — head of the HIV Vaccine Research Branch at NIH’s National Institute of Allergy and Infectious Diseases, which helped fund the study — said, “As a concept, I think this is very promising.” She added, “We need to make the genes as humanized as possible so that the human body doesn’t react to that.” According to Peggy Johnson, tests will be needed to prove that the vaccine candidate can protect against sexually acquired HIV (Fox, Reuters, 5/17). Beatrice Hahn, an HIV/AIDS researcher with the University of Alabama-Birmingham, said that the study’s findings indicate that there is “a light at the end of the tunnel,” adding, “It shows thinking outside the box is a good idea and can yield results, and we need perhaps more of these nonconventional approaches” (AP/Austin American-Statesman, 5/18).

Hildegund Ertl, a virus expert at the Wistar Institute in Philadelphia, said, “It is a very innovative approach but currently, in my mind, still far from clinical use.” Ertl added that because most people have been exposed to adeno-associated viruses through cold viruses, they would be “likely to mount an immune response” to the vaccine. According to Phillip Johnson, most people have not been exposed to the strain of the adeno-associated virus that the researchers used as the carrier. He added that they “will be certainly looking at that as part of our Phase I testing in humans” (Philadelphia Inquirer, 5/18).

Reprinted with kind permission from http://www.kaisernetwork.org. You can view the entire Kaiser Daily Health Policy Report, search the archives, or sign up for email delivery at http://www.kaisernetwork.org/dailyreports/healthpolicy. The Kaiser Daily Health Policy Report is published for kaisernetwork.org, a free service of The Henry J. Kaiser Family Foundation.

© 2009 Advisory Board Company and Kaiser Family Foundation. All rights reserved.

The Denver Post on Friday examined efforts to establish needle-exchange programs in Colorado to reduce the risk of HIV and hepatitis C among injection drug users. According to the Post, 185 cities in Colorado have needle-exchange programs, but legislation that would have legalized needle exchanges statewide did not advance in the Legislature this year. “The issue is more complex than it perhaps first appears,” Evan Dreyer, a spokesperson for Gov. Bill Ritter (D), said, adding that “law enforcement and the Colorado Department of Public Health and Environment both expressed serious reservations” about a proposal that would have legalized needle-exchanges statewide.

A coalition of public health officials, treatment providers and advocates are increasing efforts to establish a needle-exchange program in Denver, the Post reports. The Denver Drug Strategy Commission in February recommended that Mayor John Hickenlooper consider a pilot needle-exchange program, DDSC Director Karla Maraccini said. The commission is looking at different programs to develop a model following Hickenlooper’s request for additional research. However, Denver District Attorney Mitch Morrissey has concerns that a local needle-exchange program would violate state law, according to Morrissey’s spokesperson Lynn Kimbrough. Eric Brown, a spokesperson for Hickenlooper, added, “Anything in contradiction to city or state law would have to be carefully considered.”

Proponents of needle-exchange programs say they prevent HIV and hepatitis C, but opponents say they condone injection drug use. Mark Thrun, director of HIV prevention for Denver Public Health, said, adding that needle-exchange programs prevent IDUs from “getting these chronic, potentially fatal diseases” and give public health workers “an opportunity to link them into treatment; and it lessens the economic burden on the already overburdened health care system.” Thrun noted that several studies have found that needle-exchange programs do not encourage or prolong injection drug use and make IDUs more likely to seek treatment. In addition, a 2005 CDC study found that 86% of exchange programs make treatment referrals and that more than 80% offer counseling and testing for HIV/AIDS and hepatitis C.

Nancy Steinfurth, executive director of the Hep C Connection, noted that an estimated 10% of HIV cases and 70% of hepatitis C cases are transmitted through needles (Auge, Denver Post, 5/15).

Reprinted with kind permission from http://www.kaisernetwork.org. You can view the entire Kaiser Daily Health Policy Report, search the archives, or sign up for email delivery at http://www.kaisernetwork.org/dailyreports/healthpolicy. The Kaiser Daily Health Policy Report is published for kaisernetwork.org, a free service of The Henry J. Kaiser Family Foundation.

© 2009 Advisory Board Company and Kaiser Family Foundation. All rights reserved.